A–Z Glossary

Prothrombin G20210A mutation

The prothrombin G20210A mutation is an inherited thrombophilia associated with increased thrombin production and a higher risk of venous clots.

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Clotting disorders and thrombophilia in pregnancy

Clotting disorders and thrombophilia in pregnancy

Why pregnancy increases clotting risk Pregnancy produces a carefully balanced shift in hemostasis. Levels of several clotting factors rise, natural anticoagulant activity changes, fibrinolysis is reduced, and venous blood flow from the legs can slow as the uterus enlarges. Together with vessel wall changes and reduced mobility in some pregnancies, these factors fit Virchow’s triad: […]