A–Z Glossary

Polysubstance Use

Polysubstance use involves using multiple substances, either together or within overlapping periods, which can increase health risks through drug interactions.

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Alcohol and drug use risks during pregnancy

Alcohol and drug use risks during pregnancy

Why substances matter biologically in pregnancy The placenta is not a perfect filter. Alcohol, nicotine, cannabinoids, opioids, stimulants, and many sedatives can cross into the fetal circulation. Fetal metabolism is immature, so substances and their metabolites may persist longer than they would in an adult. At the same time, the embryo and fetus are undergoing […]