A–Z Glossary

Factor V Leiden

Factor V Leiden is a common inherited thrombophilia that increases clot risk, especially when two copies are inherited or clots occurred previously.

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Clotting disorders and thrombophilia in pregnancy

Clotting disorders and thrombophilia in pregnancy

Why pregnancy increases clotting risk Pregnancy produces a carefully balanced shift in hemostasis. Levels of several clotting factors rise, natural anticoagulant activity changes, fibrinolysis is reduced, and venous blood flow from the legs can slow as the uterus enlarges. Together with vessel wall changes and reduced mobility in some pregnancies, these factors fit Virchow’s triad: […]